CryoEM of myosin at work and at rest, in health and disease
- Abstract number
- 281
- Corresponding Email
- [email protected]
- Session
- Cryo-Electron Microscopy
- Authors
- David Klebl (3), Cristina Risi (1), Sean McMillian (3), Betty Virok (1), Michele Stofella (3), Bipasha Barua (2), Marta Giralt-Pujol (3), Frank Sobott (3), Vitold Galkin (1), Donald Winkelmann (2), Peter Knight (3), Stephen Muench (3), Howard White (1), Charlotte Scarff (3)
- Affiliations
-
1. Eastern Virginia Medical School
2. Rutgers University
3. University of Leeds
- Keywords
CryoEM, myosin, time-resolved cryoEM, structure
- Abstract text
Myosins are ATP-driven molecular motors that produce force and movement in cells in association with actin filaments. They are responsible for a diverse range of functions from cell division to muscle contraction and mutations within myosins are linked to a range of diseases, including heart disease and cancer. Understanding of how myosin motors function and their involvement in disease is being significantly enhanced by cryoEM studies. Here, we present how cryoEM is enabling us to understand how actomyosin generates force and how myosin at rest is implicated in disease.